Thermo Fisher Scientific RyR2 Polyclonal Antibody
RyR2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 연구용 분석에 적합. 인간 및 생쥐 시료 반응성. 고순도 친화 크로마토그래피 정제, 안정적 PBS/glycerol 저장 버퍼 구성.
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Thermo Fisher Scientific RyR2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acids 4868–4967 of human RYR2 (NP_0010262) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.16 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804131 |
Product Specific Information
- Immunogen sequence: EHTGQESYVW KMYQERC
- Positive samples: Mouse heart
- Cellular location: Membrane, multi-pass membrane protein, sarcoplasmic reticulum membrane
Target Information
Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are key components of intracellular junctions, converting membrane depolarization into Ca²⁺ release from internal stores. The alpha1-subunit of DHPR interacts with RyR via a cytoplasmic loop, and phosphorylation of DHPR alpha1 may modulate this interaction. Mutations in DHPR alpha1 cause excitation-contraction uncoupling, leading to muscular dysgenesis. Cells lacking RyR also exhibit reduced Ca²⁺ current density and lack excitation-contraction coupling.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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