Thermo Fisher Scientific EDG6 Polyclonal Antibody
인간 시료에서 EDG6 단백질을 검출하는 Rabbit Polyclonal Antibody. IHC(Paraffin) 적용 가능, 항원 친화 크로마토그래피로 정제. PBS 버퍼에 0.1% sodium azide 포함, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 8–19 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from C-terminus of human EDG6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2184890 |
Product Specific Information
PA1-32559 detects EDG6 from human samples.
Target Information
EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG6 (S1P4) is sphingosine-1-phosphate.
There are 8 known members of the EDG receptor family, which mediate growth-related effects such as:
- Induction of cellular proliferation
- Alterations in differentiation and survival
- Suppression of apoptosis
EDG receptors also evoke cellular effector functions dependent on cytoskeletal responses such as:
- Contraction
- Secretion
- Adhesion
- Chemotaxis
These receptors are developmentally regulated, differ in tissue distribution, and couple to multiple G proteins to signal through ras, MAP kinase, rho, phospholipase C, and several protein tyrosine kinases.
EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.
The new designation for EDG6 (S1P4) receptor is sphingosine 1-phosphate receptor-4 (S1P4).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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