Thermo Fisher Scientific beta Tubulin Monoclonal Antibody (TBN06 (Tub 2.5))
베타 튜불린을 검출하는 마우스 모노클로날 항체로, Western blot, IHC, ICC/IF 등 다양한 응용 가능. 광범위한 종에 반응하며, 연구용 단백질 검출의 로딩 컨트롤로 적합. 액상 형태, 4°C 보관, Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL | View 27 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | View 7 publications |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Cat, Human, Mouse, Plant, Rat, Zebrafish |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TBN06 (Tub 2.5) |
| Immunogen | Purified tubulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10990122 |
Product Specific Information
MA5-11732 targets Tubulin Beta in IF, IHC (P), and WB applications. It shows reactivity with Amphibian, Bovine, Chicken, Human, Insect, Mouse, Plant, Rabbit, and Rat samples.
Target Information
Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance. Mutations in the beta tubulin gene cause congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, which inhibits tubulin incorporation into microtubules. Microtubules, composed of alpha and beta tubulin dimers, are essential for chromosome segregation, intracellular transport, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for protein detection assays such as Western blotting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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