Thermo Fisher Scientific PTRH2/BIT1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

The protein encoded by this gene is a mitochondrial protein with two putative domains: an N-terminal mitochondrial localization sequence and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, releasing the peptidyl moiety from tRNA to prevent accumulation of dissociated peptidyl-tRNA that could reduce translation efficiency. This protein also regulates cell survival and death, promoting survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix. Mutations are associated with intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.