Thermo Fisher Scientific PTRH2/BIT1 Polyclonal Antibody
Human PTRH2/BIT1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 세포 생존 및 사멸 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 129 to 179 of Human Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2/BIT1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The protein encoded by this gene is a mitochondrial protein with two putative domains: an N-terminal mitochondrial localization sequence and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, releasing the peptidyl moiety from tRNA to prevent accumulation of dissociated peptidyl-tRNA that could reduce translation efficiency. This protein also regulates cell survival and death, promoting survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix. Mutations are associated with intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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