Thermo Fisher Scientific p150glued Polyclonal Antibody
Rabbit polyclonal antibody recognizing human p150glued (Dynactin 1). Validated for WB and IP applications. Supplied as liquid, 1 mg/mL, stored at 4°C. Suitable for research on dynein-dynactin complex and intracellular transport mechanisms.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1228 to 1278 of human 150 kDa Dynein-Associated Polypeptide (Dynactin 1, UniProt ID: Q14203-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in various cellular processes including ER-to-Golgi transport, lysosome and endosome movement, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
This subunit interacts with dynein intermediate chain and binds microtubules via a conserved CAP-Gly domain at its N-terminus. Alternative splicing produces multiple isoforms. Mutations in this gene are associated with distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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