Thermo Fisher Scientific Colon carcinoma laminin binding protein Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: 40S ribosomal protein SA.

Target Information

Laminins are extracellular matrix glycoproteins and major noncollagenous constituents of basement membranes. They play roles in cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Laminin effects are mediated through cell surface receptors, including integrins and non-integrin laminin-binding proteins.

This gene encodes a high-affinity, non-integrin laminin receptor 1 (also known as 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP), and p40 ribosome-associated protein). Its amino acid sequence is highly conserved, indicating a key biological function. Expression is elevated in colon carcinoma and lung cancer cells, correlating with invasive and metastatic phenotypes. Multiple pseudogene copies exist due to retropositional events. Two alternatively spliced transcript variants encode the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.