Thermo Fisher Scientific CD127/IL7R Monoclonal Antibody (IL7R, 2751)
인간 CD127/IL7R 단백질을 인식하는 Mouse IgG2c 단일클론 항체입니다. Western blot 및 Peptide array에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. PBS 버퍼에 0.05% BSA 및 sodium azide 포함, 4°C에서 보관합니다.
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- 3575-MSM1-P0
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL7R, 2751 |
| Immunogen | Recombinant fragment (aa 21–236) of human CD127 protein (IL7R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD127 (Interleukin-7 receptor, IL7R) is a glycoprotein involved in the regulation of lymphopoiesis. The cellular response to CD127 depends on the presence of the IL7R receptor, which forms an active alpha/gamma chain heterodimer.
The gamma(c) chain, also associated with the interleukin-2 receptor, mainly activates signal transduction, while the alpha chain determines specific signaling through cytoplasmic molecules.
CD127 promotes proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells.
Dysfunction of CD127 is associated with severe combined immunodeficiency and T cell negative/B cell negative/NK positive SCID.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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