Thermo Fisher Scientific HMGB1 Polyclonal Antibody
HMGB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 연구용에 최적화.
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Thermo Fisher Scientific HMGB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 150–200 of human High Mobility Group Protein B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. Damaged or necrotic cells release HMGB1 extracellularly, where it functions as a proinflammatory cytokine.
Mouse HMGB1 consists of a 215 amino acid single-chain polypeptide with three domains: two positively charged DNA-binding domains (HMG box A, aa 9–79; box B, aa 89–162) and a negatively charged 30 aa C-terminal acidic tail.
Residues 28–44 and 180–185 contain nuclear localization signals (NLS). The B box mediates cytokine activity, while the A box interacts with transcription factors. HMGB1 promotes monocyte migration, cytokine secretion, and T cell–dendritic cell interaction.
It signals through RAGE and possibly TLR2/TLR4 receptors. HMGB1 is conserved and ubiquitous in nuclei and cytoplasm, essential for inflammation during sterile and infection-associated responses.
Elevated HMGB1 levels are associated with tissue injury, infection, endotoxemia, sepsis, arthritis, and ischemia-reperfusion injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: HMGB1-101AP_HMGB1_P09429-1_Rabbit.svg, HMGB1-101AP_HMGB1_P09429-1_Rabbit_PDP.jpeg)
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