Thermo Fisher Scientific Phospho-CSF1R (Tyr723) Polyclonal Antibody
Human CSF1R 단백질의 Tyr723 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 0.76 mg/mL 농도, PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y723 of human CSF1R (NP_005202.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.76 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914902 |
Product Specific Information
- Target localization: Cell membrane, single-pass type I membrane protein
- Immunogen sequence: DTYVE
Target Information
CSF1R (also known as FMS or CD115) is a tyrosine kinase transmembrane receptor involved in the production, differentiation, and function of macrophages. Ligand binding (CSF1 or IL34) activates receptor kinase activity via oligomerization and transphosphorylation.
It regulates survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes such as macrophages and monocytes.
CSF1R also promotes the release of proinflammatory chemokines and plays a key role in innate immunity and inflammatory processes.
Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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