Thermo Fisher Scientific ARRB1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Protein Sequence:
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

Target Information

Beta Arrestin 1 is a member of a family of proteins widely expressed, especially abundant in the central nervous system. It serves as an adaptor or scaffold molecule essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.
After ligand binding and GPCR phosphorylation by G-protein receptor kinases (GRKs), Beta Arrestin 1 in the cytosol is phosphorylated by ERK1/2 on serine 412 in a negative feedback mechanism. It binds to phosphorylated receptors at the plasma membrane, followed by dephosphorylation and receptor internalization, leading to activation of the Ras–Raf–ERK signaling pathway.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.