Thermo Fisher Scientific Human Nicastrin Synthetic Peptide
휴먼 Nicastrin의 C-말단 17개 아미노산 서열로 구성된 합성 펩타이드. PA5-20303 항체의 블로킹 펩타이드로 사용 가능. 감마-시크리타제 복합체 연구에 활용. 정제된 액상 형태로 제공되며, PBS(0.1% BSA, 0.02% sodium azide) 용액에 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human nicastrin.
PEP-0428 can be used as a blocking peptide with polyclonal antibody PA5-20303.
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is part of the multimeric gamma-secretase complex. This protein cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein and may act as a stabilizing cofactor for gamma-secretase complex assembly.
Cleavage of beta-amyloid precursor protein generates amyloid beta peptide, the main component of neuritic plaques characteristic of Alzheimer’s disease. However, the exact role of Nicastrin in Alzheimer’s disease remains uncertain.
Mutations in NCSTN are associated with familial acne inversa, and a pseudogene is located on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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