Thermo Fisher Scientific SCN9A Polyclonal Antibody

Thermo Fisher Scientific SCN9A Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
RAYRRYRLRQN VKNISSIYIK DGDRDDDLLN KKDMAFDNVN ENSSP

Highest antigen sequence identity to the following orthologs:

• Mouse: 91%
• Rat: 89%

Target Information

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share organizational similarity, possessing two short intracellular amino and carboxyl termini, two short membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of the ENaC protein: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure.

ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.