Thermo Fisher Scientific Heme Oxygenase-1 Monoclonal Antibody (GTS-1)

Applications

Tested Dilution

Publications

Western Blot (WB)

5-10 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5-10 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

GTS-1

Immunogen

Microsomal fraction of transformed mouse T-cell transfected with rat heme oxygenase-1 (WR19LrHO-1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HO-1,uniProtId:P06762-1,ncbiNodeId:10114,antigenRange:1-289,antigenLength:289,antigenImageFileName:13060-100UG_HO-1_P06762-1_House_mouse.svg,antigenImageFileNamePDP:13060-100UG_HO-1_P06762-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

no preservative

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 50 µL of distilled water; final concentration will be 2 mg/mL. If further dilution is needed, dilute this stock with 10mM PBS, pH 7.4 + 1% BSA immediately before use.

Target Information

Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.