Thermo Fisher Scientific Abraxas Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, predicted to react with Orangutan, Monkey, Crab-eating macaque, and White-tufted-ear marmoset

Target Information

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target.
CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.
Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of either CCDC98 or RAP80 exhibit increased sensitivity to ionizing radiation, though not as much as BRCA1-depleted cells, suggesting these proteins control part of the DNA damage response role of BRCA1.
At least two isoforms of CCDC98 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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