Thermo Fisher Scientific Abraxas Polyclonal Antibody
Abraxas 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 IHC(P)에서 사용 가능하며, 인간 및 유사 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로 4°C에서 보관. DNA 손상 반응 연구에 적합.
- 카탈로그번호
- IHC00630x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Abraxas Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 409 of human Abraxas (coiled-coil domain containing 98) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Orangutan, Monkey, Crab-eating macaque, and White-tufted-ear marmoset
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target.
CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.
Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells depleted of either CCDC98 or RAP80 exhibit increased sensitivity to ionizing radiation, though not as much as BRCA1-depleted cells, suggesting these proteins control part of the DNA damage response role of BRCA1.
At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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