Thermo Fisher Scientific MADD Polyclonal Antibody
MADD 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC 및 IHC(P) 실험에 사용 가능. 인간 반응성, 비결합형 액상 형태, 항원 친화 크로마토그래피로 정제. TNFR1 신호전달 및 MAP kinase 활성화 연구에 적합.
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Thermo Fisher Scientific MADD Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:50–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1597 and 1647 of human MAP-kinase activating death domain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, Bovine, Dog, Horse, Guinea pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee
Target Information
Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF.
MADD (Mitogen Activated Protein (MAP)-kinase activating death domain protein) associates with the death domain of TNFR1 through its own C-terminal death domain, critical for TNFR1 signal generation.
Overexpression of MADD activates MAP kinases ERK and JNK and induces phosphorylation of cytosolic phospholipase A2, linking TNF and MAP kinase activation with arachidonic acid release.
MADD shows 98% homology with DENN (differentially expressed in neoplasmic vs. normal cells) and 93% sequence conservation with Rab3, a GDP/GTP exchange protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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