Thermo Fisher Scientific SCP2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
ATGLAQCAEL CWQLRGEAGK RQVPGAKVAL QHNLGIGGAV VVTLYKMGFP EAASSFRTHQ IEAVPTSSAS DGFKANLVFK EIEKKLEEEG EQFVKKI

• Highest antigen sequence identity to orthologs:
  • Mouse: 94%
  • Rat: 92%

Target Information

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), resulting from transcription initiation from two independently regulated promoters.

• The proximal promoter encodes the longer SCPx protein.
• The distal promoter encodes the shorter SCP2 protein.
  Both share a common C-terminus.

SCPx functions as a peroxisome-associated thiolase involved in oxidation of branched-chain fatty acids, while SCP2 acts as an intracellular lipid transfer protein.
This gene is highly expressed in lipid metabolism organs and may be implicated in Zellweger syndrome, where peroxisomal deficiency impairs bile acid synthesis.
Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.