Thermo Fisher Scientific HYAL2 Polyclonal Antibody

Applications and Tested Dilution

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
APPIFTGRPF VVAWDVPTQD CGPRLKVPLD LNAFDVQASP NEGFVNQNIT IFYRDRLGLY PRFDSAGRSV HGGVPQNVSL WAHRK

Antigen sequence identity:

• Mouse: 81%
• Rat: 80%

Target Information

This gene encodes a weak acid-active hyaluronidase. The encoded protein is structurally similar to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, a major glycosaminoglycan of the extracellular matrix, and its fragments are involved in cell proliferation, migration, and differentiation.

Although previously thought to be a lysosomal enzyme active below pH 4, the encoded protein is likely a GPI-anchored cell surface protein. It also serves as a receptor for the oncogenic Jaagsiekte sheep retrovirus. The gene is located in chromosome region 3p21.3, associated with tumor suppression, and has two alternatively spliced transcript variants differing in the 5′ UTR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.