Thermo Fisher Scientific GAPDH Polyclonal Antibody
Western blot, IHC, ICC 등 다양한 응용에 적합한 GAPDH 폴리클로날 항체로, Rabbit IgG 기반의 비결합형 액상 제품입니다. 다양한 종에 반응하며, 단백질 로딩 컨트롤로 유용합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human GAPDH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792231 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Cat (100%), Pig (100%), Rabbit (100%), Rhesus Monkey (100%).
- Positive Control: A431, H1299, HeLa, HepG2, Neuro2A, BCL-1, Raw264.7, SH-SY5Y.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme involved in glycolysis. It exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphate in the presence of NADPH.
Beyond glycolysis, GAPDH participates in processes such as DNA replication, DNA repair, nuclear RNA export, membrane fusion, and microtubule bundling. It also plays roles in apoptosis and neurodegenerative disease mechanisms.
GAPDH interacts with various proteins, including amyloid precursor protein (linked to Alzheimer’s disease) and Huntingtin (linked to Huntington’s disease). Due to its high expression across tissues, GAPDH is widely used as a protein loading control in Western blot analysis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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