Thermo Fisher Scientific DNAJB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total DNAJB2.

Target Information

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family.
DnaJ heat shock-induced proteins originate from Escherichia coli and are regulated by the htpR protein. These proteins play a critical role in the HSP70 chaperone system by interacting with HSP70 to stimulate ATP hydrolysis.
They contain cysteine-rich zinc finger regions forming peptide-binding domains responsible for chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in protein degradation, exocytosis, and endocytosis.
DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.