Thermo Fisher Scientific CARD8 Polyclonal Antibody
CARD8 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되어 순도 95% 이상. 인간 시료에 반응하며, 액상 형태로 1 mg/mL 농도. 세포사멸 관련 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human CARD8 (amino acids 1–537) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719363 |
Product Specific Information
This antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Apoptosis is a key process in development and disease. Cell death signals are mediated by proteins containing death domains (DD), death effector domains (DED), and caspase recruitment domains (CARD). CARD-containing proteins include caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC.
CARD8 is a novel CARD-containing protein that interacts with DRAL, a p53-responsive protein involved in apoptosis induction, as well as caspase-1 and its related proteins ICEBERG and pseudo-ICE. Although studies differ on whether CARD8 acts as a pro- or anti-apoptotic protein, it is suggested to function as an adaptor molecule regulating caspase-1 and NF-κB activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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