Thermo Fisher Scientific RAPGEF5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
DFLLTYTVFMT TDDLCQALLR HYSAKKYQGK EENSDVPRRK RKVLHLVSQW IALYKDWLPE DEHSKMFLKT IYRNVLD

Highest antigen sequence identity to the following orthologs:

• Mouse: 95%
• Rat: 95%

Target Information

Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as Repac, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.

Repac, also known as Rap guanine nucleotide exchange factor 5 (RAPGEF5), is a 580 amino acid protein expressed in brain and testis, with weaker expression in heart, placenta, lung, pancreas, and small intestine. Existing as two alternatively spliced isoforms, the Repac gene is conserved in cow, mouse, and rat. The gene encoding Repac maps to human chromosome 7p15.3, with high expression of this region linked to positive response to erlotinib therapy in non-small-cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.