Thermo Fisher Scientific PLSCR1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000 dilution

Species Reactivity

• Human
• Mouse

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

PLSCR1 (NP_066928.1, 1–318 a.a) full-length human protein.

Conjugate

• Unconjugated

Form

• Liquid

Concentration

• See Label

Purification

• Affinity chromatography

Storage Buffer

• PBS, pH 7.4

Contains

• No preservative

Storage Conditions

• −20°C
• Avoid freeze/thaw cycles

Shipping Conditions

• Ambient (domestic)
• Wet ice (international)

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Product Specific Information

Sequence of this protein is as follows:
MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI DFMFFESTGS QEQKSGVW

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Target Information

PLSCR1 (Phospholipid Scramblase 1)은 칼슘 의존성 혈장막 단백질로, 세포질 내 칼슘 유입 시 인지질의 층간 이동을 매개하여 세포막 인지질 재배열 및 손상 또는 세포사멸 시 phosphatidylserine의 표면 노출을 유도합니다.
Interferon 및 기타 cytokine에 의해 발현이 유도되며, cytokine 신호 전달 경로에서도 기능합니다.
EGF 자극 시, PLSCR1의 tyrosine 69 및 74가 인산화되어 Shc와 상호작용하며, Src kinase 활성화를 EGF receptor 자극과 연결합니다.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.