Thermo Fisher Scientific Phospho-Tau protein (Ser579) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting Tau functions as a linker between both. Axonal polarity is influenced by TAU/MAPT localization within the neuronal cell body. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize it.

In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs Tau’s microtubule-binding function, destabilizing microtubules and leading to neuronal degeneration. Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative diseases such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.