Thermo Fisher Scientific DYNC1H1 Polyclonal Antibody
DYNC1H1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간과 생쥐 시료에 반응. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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Thermo Fisher Scientific DYNC1H1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 | - |
| In Situ Hybridization (ISH) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 4202–4236 from the C-terminal region of human DYNC1H1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634905 |
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, suggesting its role in tumor progression. It is often observed in the cytoplasm in various cancer tissues, indicating localization regulation. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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