Thermo Fisher Scientific Human DACT2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 12 amino acids near the amino terminus of human Dact2.
PEP-0749 can be used as a blocking peptide with polyclonal antibody PA5-20629.

Target Information

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in postnatal tissues such as the brain.
One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus, kidneys, and salivary gland.
Dact2 is thought to play a role distinct from that of Dact1, with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.