Thermo Fisher Scientific ATF7 Polyclonal Antibody

Thermo Fisher Scientific ATF7 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

ATF7 plays important functions in early cell signaling. It binds the cAMP response element (CRE) sequence present in many viral and cellular promoters. Acts as an activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Although it has no intrinsic transcriptional activity, it activates transcription upon formation of JUN or FOS heterodimers. It can also bind TRE promoter sequences when heterodimerized with JUN family members. Isoform 4 (ATF-A0) acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter, while Isoform 5 (ATF-4) acts as a negative regulator inhibiting both ATF2 and ATF7 transcriptional activities, potentially by sequestrating the Thr-53 phosphorylating kinase in the cytoplasm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.