Thermo Fisher Scientific CD282 (Toll-Like Receptor 2) Recombinant Rabbit Monoclonal Antibody (TLR2/3894R)

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

Predicted to react with monkey and dog.

Target Information

TLR2 (Toll-Like Receptor 2) is a member of the Toll-like receptor family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 acts through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors, including PKC alpha/beta and NF-kappa-B. It can form heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins.

TLRs are highly conserved from Drosophila to humans. TLR2 is expressed abundantly in peripheral blood leukocytes and mediates host responses to Gram-positive bacteria and yeast via NF-kappaB activation. It recognizes pathogen-associated molecular patterns (PAMPs) and induces cytokine production necessary for effective immunity.

TLR2 is expressed in human tonsils, microglia, lymph nodes, appendices, and activated B-cells. CD14+ monocytes show the highest expression, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. Expression is modulated by immune response modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-gamma, and TNF downregulate it in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.