Thermo Fisher Scientific Nephrin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Nephrin.

Target Information

Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end-stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2.
Nephrin, a recently identified protein, is a member of a group of podocyte proteins that constitute a major component of the slit diaphragm, especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier.
Mutations in the gene for Nephrin have been reported to lead to congenital nephrosis. Three novel podocyte proteins—Podocin, Nephrin, and α-Actinin 4—have been identified in congenital and experimental models of proteinuria.
Nephrin may be involved in anti-apoptotic activity in podocyte slit diaphragms, potentially associated with VEGF signaling, and plays a role in the development or function of the kidney glomerular filtration barrier by anchoring the podocyte slit diaphragm to the actin cytoskeleton.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.