Thermo Fisher Scientific Calretinin/Calbindin 2 (Mesothelioma Marker) Recombinant Rabbit Monoclonal Antibody (CALB2/7029R)
Calretinin(CALB2) 단백질을 인식하는 재조합 토끼 단클론 항체로, 중피종 표지자 연구에 적합. Western blot 및 IHC 등 다양한 응용 가능. 인간 시료 반응성, HEK293 발현 시스템 기반. 24개월 안정성 보유, 단백질 A 정제.
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Thermo Fisher Scientific Calretinin/Calbindin 2 (Mesothelioma Marker) Recombinant Rabbit Monoclonal Antibody (CALB2/7029R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CALB2/7029R |
| Immunogen | Recombinant human Calretinin (Calbindin 2) protein fragment (around aa23–242) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody stability: 24 months
- Positive control: Human brain, testis, or mesothelioma tissue
- Cellular localization: Cytoplasm, nucleus
- Specificity: Recognizes a ~29 kDa protein identified as Calretinin (Calbindin 2), a vitamin D-dependent calcium-binding protein involved in calcium signaling.
- Diagnostic relevance: Useful for differentiating mesothelioma from adenocarcinomas of the lung, and adrenal cortical neoplasms from pheochromocytomas.
Target Information
Calretinin is encoded by the CALB2 gene on chromosome 16. It belongs to the troponin C superfamily and contains six EF-hand structural motifs that enable calcium binding. Calretinin functions in calcium signaling, buffering, and neuronal excitability modulation. It is expressed in mesothelium, mast cells, neural cells, hair follicles, and fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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