Thermo Fisher Scientific Calretinin/Calbindin 2 (Mesothelioma Marker) Recombinant Rabbit Monoclonal Antibody (CALB2/7029R)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Peptide Array (Array)

Assay-dependent

-

Immunoelectrophoresis (IE)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

CALB2/7029R

Immunogen

Recombinant human Calretinin (Calbindin 2) protein fragment (around aa23-242). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Calretinin,uniProtId:P22676-1,ncbiNodeId:9606,antigenRange:23-242,antigenLength:271,antigenImageFileName:794-RBM12-P1_Calretinin_P22676-1_Rabbit.svg,antigenImageFileNamePDP:794-RBM12-P1_Calretinin_P22676-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is stable for 24 months.

Positive Control: Human brain, testis or mesothelioma tissue. Cellular Localization: Cytoplasm. Nucleus.

Specificity Comments: It recognizes a protein of about 29kDa, which is identified as Calretinin (also known as Calbindin 2). Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is present in subsets of neurons throughout the brain and spinal chord, including sensory ganglia. Antibody to calretinin is useful in differentiating mesothelioma from adeno carcinomas of the lung. It also aids in differentiating adrenal cortical neoplasms from pheochromocytomas.

Target Information

Calretinin is encoded by the CALB2 gene located on chromosome 16. It is a troponin C superfamily protein having six EF-hand structural motifs. The EF motif allows the protein to bind calcium, and function in calcium signaling, calcium buffering, and modulating neuronal excitability. Calretinin is expressed in the mesothelium, mast cells, some neural cells, hair follicles, and fat cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.