Thermo Fisher Scientific NR2E3 Monoclonal Antibody (2A12)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.3 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2A12

Immunogen

NR2E3 (AAH41421, 1 a.a. approximately 322 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PNR,uniProtId:Q9Y5X4-1,ncbiNodeId:9606,antigenRange:1-410,antigenLength:410,antigenImageFileName:H00010002-M01_PNR_Q9Y5X4-1_House_mouse.svg,antigenImageFileNamePDP:H00010002-M01_PNR_Q9Y5X4-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MCPVDKAHRN QCQACRLKKC LQAGMNQDAV QNERQPRSTA QVHLDSMESN TESRPESLVA PPAPAGRSPR GPTPMSAARA LGHHFMASLI TAETCAKLEP EDADENIDVT SNDPEFPSSP YSSSSPCGLD SIHETSARLL FMAVKWAKNL PVFSSLPFRD QVILLEEAWS ELFLLGAIQW SLPLDSCPLL APPEASAAGG AQGRLTLASM ETRVLQETIS RFRALAVDPT EFACMKALVL FKPETRGLKD PEHVEALQDQ SQVMLSQHSK AHHPSQPVRF GKLLLLLPSL RFITAERIEL LFFRKTIGNT PMEKLLCDMF KN

Target Information

NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.