Thermo Fisher Scientific SCO2 Polyclonal Antibody

Thermo Fisher Scientific SCO2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).

Target Information

Synthesis of cytochrome c oxidase 2 (SCO2) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.
Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding.
Recent studies suggest that SCO2 expression is regulated by p53, and a decrease in p53 expression—as observed in numerous tumors and cell lines—leads to reduced SCO2 expression, shifting metabolism from normal aerobic respiration toward glycolytic ATP production.
Defects in the SCO2 protein are associated with fatal infantile cardioencephalomyopathy and COX deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.