Thermo Fisher Scientific SCO2 Polyclonal Antibody
SCO2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제됨. p53 관련 대사 연구 및 미토콘드리아 단백질 분석에 적합.
- 판매단위
- pk
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Thermo Fisher Scientific SCO2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human SCO2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719936 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
Synthesis of cytochrome c oxidase 2 (SCO2) was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.
Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding.
Recent studies suggest that SCO2 expression is regulated by p53, and a decrease in p53 expression—as observed in numerous tumors and cell lines—leads to reduced SCO2 expression, shifting metabolism from normal aerobic respiration toward glycolytic ATP production.
Defects in the SCO2 protein are associated with fatal infantile cardioencephalomyopathy and COX deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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