Thermo Fisher Scientific POM121 Polyclonal Antibody
Rabbit polyclonal antibody against human POM121 for IHC and IHC-P applications. Recognizes nuclear envelope pore membrane protein involved in nuclear pore complex formation. Supplied as liquid, unconjugated, 0.05 mg/mL, stored at 4°C or -20°C. For rese...
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
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Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POM121. Recombinant protein control fragment (Product #RP-99569) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790834 |
Product Specific Information
Immunogen sequence:
HHSSSSTPLA ADKESQGEKA ADTTPRKKQN SNSQSTPGSS GQRKRKVQLL PSRRG
Target Information
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121), or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spliced isoforms and belongs to the POM121 family.
Encoded by a gene on human chromosome 7q11.23, POM121 is highly conserved and localizes to the nuclear and endoplasmic reticulum membranes.
As an essential component of the nuclear pore complex (NPC), POM121 is required for nuclear envelope formation and may contribute to NPC biogenesis. It associates with the central spoke ring complex and anchors pore complex components to the pore membrane via its F-X-F-G repeat-containing domain. Overexpression of POM121 can induce formation of cytoplasmic annulate lamellae (AL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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