Thermo Fisher Scientific BRCA1 Polyclonal Antibody
BRCA1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP에 사용 가능하며, 액상 형태로 4°C 보관. 암 관련 유전자 연구 및 DNA 손상 복구 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BRCA1 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | BRCA1 protein region between amino acids 250–300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that helps maintain genomic stability and acts as a tumor suppressor. It interacts with DNA damage sensors and signal transducers to form the BASC complex (BRCA1-associated genome surveillance complex). BRCA1 also associates with RNA polymerase II and histone deacetylase complexes, contributing to transcription regulation and DNA repair.
Mutations in BRCA1 are linked to approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects its localization and function, with several disease-associated variants identified. A related pseudogene is located on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
제품 이미지
(해당 제품 관련 이미지는 본문 하단에 표시됩니다.)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.