Thermo Fisher Scientific BRE Polyclonal Antibody
Thermo Fisher Scientific의 BRE Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western Blot, ICC/IF, IP에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, BRCC45 단백질 복합체 연구에 활용됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing sequence within amino acids 9–328 (Q9NXR7) of BRE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155399 |
Product Specific Information
- Recommended positive controls: HeLa, 293T, A431, C8D30, rat testis
- Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (85%), Xenopus laevis (91%), Chicken (97%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
BRCC45 was initially suggested to be a housekeeping protein highly expressed in brain and reproductive organs. Later studies showed BRCC45 forms a complex with BRCA1, BRCA2, RAD51, and BRCC36, exhibiting ubiquitin E3 ligase activity that enhances cellular survival following DNA damage.
It may also act as an anti-apoptotic protein by inhibiting BID-induced mitochondrial apoptosis. Elevated BRCC45 levels have been observed in hepatocellular carcinomas, suggesting a role in tumorigenesis.
At least three isoforms of BRCC45 are known.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm in California.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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