Thermo Fisher Scientific PKC alpha Polyclonal Antibody
PKC alpha 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(Paraffin)에 사용 가능. Human, Mouse, Rat 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로 세포 신호전달 및 단백질 인산화 연구에 적합.
- 카탈로그번호
- PA522160
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–250 of PKC alpha (Uniprot ID: P17252) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11155801 |
Product Specific Information
- Recommended positive controls: H1299, Jurkat, U87-MG, SK-N-SH, IMR32, SK-N-AS, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2
- Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (89%), Xenopus laevis (92%), Rabbit (99%), Chicken (95%), Rhesus Monkey (100%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. PKC family members phosphorylate diverse protein targets and participate in various cellular signaling pathways. They also serve as major receptors for phorbol esters, known tumor promoters.
PKC alpha plays roles in cell adhesion, transformation, cell cycle checkpoint regulation, and cell volume control. Knockout studies suggest its importance in cardiac contractility and Ca²⁺ handling in myocytes.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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