Thermo Fisher Scientific Phospho-JNK1 (Thr183, Tyr185) Recombinant Rabbit Monoclonal Antibody (HL1008)
Phospho-JNK1 (Thr183, Tyr185) 특이적 재조합 토끼 단클론 항체. Western blot 및 IHC(P)에서 사용 가능. Human 및 Mouse 시료 반응성. Protein A 정제, 1 mg/mL 농도, PBS buffer 보존. 장기 보관 시 -20°C 이하에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1008 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human JNK (phospho Thr183/Tyr185). The antigen corresponds to amino acid range 183–185 of the target protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911510 |
Product Specific Information
Store as a concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum.
It is a crucial mediator of insulin resistance and obesity, belonging to the MAPK superfamily of stress-activated protein kinases.
MAPKs are serine/threonine kinases activated by various extracellular stimuli, mediating signal transduction from the cell surface to the nucleus.
JNK participates in cellular processes such as proliferation, differentiation, transcription regulation, and development.
JNK pathways are activated by stress and inflammatory signals.
JNK is expressed as ten isoforms due to differential mRNA splicing, with JNK1 and JNK2 being predominant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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