Thermo Fisher Scientific Adeno-Associated Virus Capsid Protein Polyclonal Antibody
AAV 캡시드 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, ELISA, IP에 사용 가능. Rabbit IgG 기반 비결합형 항체이며, 항원 친화 크로마토그래피로 정제됨. 바이러스 연구 및 AAV 구조 분석에 적합.
- 카탈로그번호
- AAVCAP-112AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids within region 200–250 on rat 5-hydroxytryptamine receptor 1A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Proprietary buffer with 30% glycerol |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Capsid protein self-assembles to form an icosahedral capsid with T=1 symmetry, approximately 22 nm in diameter, consisting of 60 copies of three size variants (VP1, VP2, VP3) differing in their N-terminus. The capsid encapsulates the genomic ssDNA and binds to host cell heparan sulfate, using host ITGA5-ITGB1 as a coreceptor for virion attachment. This attachment induces internalization through clathrin-dependent endocytosis and triggers capsid rearrangements exposing the VP1 N-terminus, including its phospholipase A2-like region and nuclear localization signals. VP1 N-terminus may act as a lipolytic enzyme to breach the endosomal membrane and facilitate transport to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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