Thermo Fisher Scientific KMT2E Polyclonal Antibody
KMT2E 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 고순도 친화 크로마토그래피 정제 및 PBS/glycerol 버퍼 보존. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200–500 of human MLL5 (NP_0611523) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.61 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901667 |
Product Specific Information
- Positive Samples: NCI-H460, 293T, Mouse brain
- Immunogen sequence:
VELYTAFQHT PTSITLTASR VSKVNDKRRK KSGEKEQHIS KCKKAFREGS RKSSRVKGSA PEIDPSSDGS NFGWETKIKA WMDRYEEANN NQYSEGVQRE AQRIALRLGN GNDKKEMNKS DLNTNNLLFK PPVESHIQKN KKILKSAKDL PPDALIIEYR GKFMLREQFE ANGYFFKRPY PFVLFYSKFH GLEMCVDART FGNEARFIRR SCTPNAEVRH EIQDGTIHLY IYSIHSIPKG TEITIAFDFD YGNCKYKVDC ACLKENPECP VLKRSSESME NINSGYETRR KKGKKDKDIS K
Target Information
The mixed lineage leukemia (MLL) gene family comprises a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family.
The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias.
MLL2 (also designated ALR) exists within a complex of proteins and is important for mouse embryonic development, potentially involved in adhesion-related cytoskeletal events affecting cell growth and survival.
The MLL2 gene maps to human locus 19q13.1, a frequent target of rearrangement or amplification in solid tumors.
MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), regulating ligand-dependent H3K4 trimethylation and expression of LXR-target genes.
MLL3 maps to human chromosome 7, often deleted in myeloid disorders, and exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus.
MLL5 localizes to the nucleus and forms intranuclear protein complexes, potentially regulating chromatin remodeling and cellular growth suppression.
The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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