Thermo Fisher Scientific SPRED1 Monoclonal Antibody (462CT2.5.1)
SPRED1 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 최적화됨. 인간 및 마우스 시료 반응성. Protein G 정제, PBS buffer에 0.09% sodium azide 포함. Spred1 관련 신호전달 연구용.
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Thermo Fisher Scientific SPRED1 Monoclonal Antibody (462CT2.5.1)
Applications
- Western Blot (WB)
Tested Dilution
- 1:100–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 462CT2.5.1 |
| Immunogen | Purified His-tagged SPRED1 protein (fragment) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897494 |
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf.
Spred proteins are implicated in negative feedback regulation of FGF signaling in embryogenesis and angiogenesis.
Expression levels of Spred1 and Spred2 proteins are inversely correlated with tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting their potential as prognostic factors and therapeutic targets in HCC.
Defects in this gene are associated with neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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