Thermo Fisher Scientific Phospho-IKK beta (Ser740) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex and phosphorylates inhibitors of NF-kappa-B on two critical serine residues, enabling polyubiquitination and degradation by the proteasome.
Free NF-kappa-B then translocates into the nucleus and activates transcription of numerous genes involved in immune response, growth control, and protection against apoptosis.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.