Thermo Fisher Scientific Periostin Monoclonal Antibody (C6)
Periostin 단백질을 인식하는 Mouse monoclonal antibody (Clone C6)로, WB 및 IHC(P) 적용 가능. Human과 Rat 반응성. Recombinant POSTN 항원을 기반으로 제작되었으며, 고순도 Protein A/G 정제. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–30 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C6 |
| Immunogen | Recombinant POSTN (Pro97–Leu230) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2912560 |
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a disulfide-linked protein originally identified as an osteoblast-specific factor. It is a secreted protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule involved in osteoblast recruitment, spreading, and attachment.
Periostin is mainly expressed in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, but is upregulated in epithelial ovarian tumors and overexpressed in breast cancer. Its expression is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGFβ1).
The protein contains a signal sequence, a cysteine-rich domain, a fourfold repeated domain homologous to insect fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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