Thermo Fisher Scientific TLR7 Polyclonal Antibody
TLR7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 시료에 반응하며, PBS buffer와 glycerol로 안정화된 액상 형태. 선천면역 관련 TLR7 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 30–230 of human TLR7 (NP_057646.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804244 |
Product Specific Information
Positive Samples:
Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, Phagosome
Immunogen sequence:
FPKTLPCDVT LDVPKNHVIV DCTDKHLTEI PGGIPTNTTN LTLTINHIPD ISPASFHRLD HLVEIDFRCN CVPIPLGSKN NMCIKRLQIK PRSFSGLTYL KSLYLDGNQL LEIPQGLPPS LQLLSLEANN IFSIRKENLT ELANIEILYL GQNCYYRNPC YVSYSIEKDA FLNLTKLKVL SLKDNNVTAV PTVLPSTLTE L
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity. TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is located near TLR8. TLR7 signals through MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion, and inflammatory responses. It recognizes pathogen-associated molecular patterns (PAMPs) on infectious agents and mediates cytokine production essential for effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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