Thermo Fisher Scientific Factor XIII A Polyclonal Antibody
Factor XIII A 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity 정제 항체입니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 600–732 of human F13A1 (NP_0001202) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.24 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805853 |
Product Specific Information
- Immunogen sequence:
LEQASLHFFV TARINETRDV LAKQKSTVLT IPEIIIKVRG TQVVGSDMTV TVEFTNPLKE TLRNVWVHLD GPGVTRPMKK MFREIRPNST VQWEEVCRPW VSGHRKLIAS MSSDSLRHVY GELDVQIQRR PSM - Positive Samples: Jurkat, SH-SY5Y, BxPC-3, Mouse testis, Rat brain, Rat testis
- Cellular Location: Cytoplasm
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as carrier molecules. Platelet factor XIII consists only of two A subunits identical to those in plasma. Upon activation by thrombin in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa. This enzyme acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains. Deficiency in factor XIII may lead to bleeding disorders, impaired wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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