Thermo Fisher Scientific DGKQ Polyclonal Antibody
Human DGKQ 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 사용 가능하며, 고순도의 항원 친화 크로마토그래피로 정제됨. 내인성 단백질(101 kDa)을 검출하며, 세포 성장 및 분화 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 700–750 of human DGK-theta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553468 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 101 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Diacylglycerol (DAG) is a key lipid second messenger produced in the nucleus and plays a critical role in regulating cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating DAG signaling, which reduces protein kinase C activity and affects the cell cycle progression of T lymphocytes.
DGK-theta, a Type V DGK, localizes mainly to the nucleus in various cell lines such as MDA-MB-453, MCF-7, PC12, and HeLa. Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) and is responsive to alpha-Thrombin stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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