Thermo Fisher Scientific AMPK gamma-1,2,3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Not specified
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
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Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200
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Product Specifications

Product Specific Information

This antibody detects endogenous protein at molecular weights of 38, 54, and 63 kDa.
Purity is >95% by SDS-PAGE.

Target Information

The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non-fermentor) kinase family, is a heterotrimeric protein composed of alpha (63 kDa), beta (30 kDa), and gamma (38 kDa) subunits.

• The alpha subunit is catalytic.
• The beta and gamma subunits are non-catalytic but interact with the active subunit in the liver.
  AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA and controls cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase.
  AMPK is activated by AMP and can also be regulated by treatment with purified protein phosphatase in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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