Thermo Fisher Scientific GNE Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GNE. Recombinant protein control fragment (Product #RP-89764). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GNE,uniProtId:Q9Y223-1,ncbiNodeId:9606,antigenRange:64-196,antigenLength:722,antigenImageFileName:PA5-52380_GNE_Q9Y223-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52380_GNE_Q9Y223-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642084

Product Specific Information

Immunogen sequence: DDFDINTRLH TIVRGEDEAA MVESVGLALV KLPDVLNRLK PDIMIVHGDR FDALALATSA ALMNIRILHI EGGEVSGTID DSIRHAITKL AHYHVCCTRS AEQHLISMCE DHDRILLAGC PSYDKLLSAK NKD

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.