ELK Biotechnology Cleaved-Caspase-1 (M211) rabbit pAb
Cleaved-Caspase-1 (M211) rabbit pAb는 인간, 생쥐, 랫트 시료에 반응하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포자멸사 관련 단백질 연구에 유용하며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Cleaved-Caspase-1 (M211) rabbit pAb
Cleaved-Caspase-1 (M211) rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Caspase-1 (M211) rabbit pAb |
| Alternative Names | CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CASP1 (AA range: 192–241) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 834 |
| Human Swiss-Prot No | P29466 |
| Cellular Localization | Cytoplasm, Cell membrane |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, which dimerize to form the active enzyme.
This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in inflammation, septic shock, and wound healing. It has been shown to induce cell apoptosis and may function in various developmental stages. Studies in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
[provided by RefSeq, Mar 2012]
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.