ELK Biotechnology CaMKIIα/δ rabbit pAb
CaMKIIα/δ rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에서 WB, IHC, IF, ELISA에 사용 가능. 합성 펩타이드(AA 256-305)로부터 제작. 54kD 밴드 검출, IgG 아이소타입. 장기 보관 시 -20°C에서 1년 안정.
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제품명
CaMKIIα/δ rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2D; CAMKD; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CaMK2 alpha/delta (AA range: 256–305) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 54 kD |
| Gene ID (Human) | 815 / 817 |
| Human Swiss-Prot No. | Q9UQM7 / Q13557 |
| Cellular Localization | Cell junction, synapse; postsynaptic density; dendritic spine; dendrite; postsynaptic lipid rafts |
| Species Reactivity | Human; Mouse; Rat |
Background
The product of this gene belongs to the serine/threonine protein kinase family, specifically the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for various aspects of plasticity at glutamatergic synapses. This calcium/calmodulin-dependent protein kinase consists of four different chains: alpha, beta, gamma, and delta. The alpha chain is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its CaM-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene (RefSeq, Nov 2008).
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