ELK Biotechnology Caldesmon rabbit pAb
Caldesmon 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 사람 Caldesmon 유래 펩타이드로 면역화되었으며, 세포질 및 세포골격에 위치한 단백질을 검출합니다. -20°C에서 1년간 보관 가능합니다.
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Caldesmon rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caldesmon rabbit pAb |
| Alternative Names | CALD1; CAD; CDM; Caldesmon; CDM |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caldesmon (AA range: 744-793) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kD |
| GeneID (Human) | 800 |
| Human Swiss-Prot No | Q05682 |
| Cellular Localization | Cytoplasm, cytoskeleton; cytoplasm, myofibril; cytoplasm, cytoskeleton, stress fiber; on thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
[provided by RefSeq, Jul 2008]
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