ELK Biotechnology CA VIII rabbit pAb

CA VIII rabbit pAb

제품 개요

ELK Biotechnology의 CA VIII rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체입니다. Carbonic anhydrase VIII 단백질을 검출하는 데 사용되며, WB, IHC, IF, ELISA 등 다양한 응용에 적합합니다.

제품 사양

Background

The protein encoded by the CA8 gene was initially named CA-related protein due to sequence similarity with other carbonic anhydrase genes. However, this gene product lacks enzymatic carbonic anhydrase activity. Despite this, it retains the designation based on sequence identity. The absence of CA8 transcription in the cerebellum of lurcher mutant mice indicates its role in neurological function. Mutations in CA8 are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms are linked to osteoporosis, and overexpression in osteosarcoma cells suggests an oncogenic role. Alternative splicing produces multiple transcript variants.